HIPK3, a mammalian homolog of YAK1, is a novel 130 kDa nuclear co-factor that belongs to the HIPK protein family. Members of this family localize to nuclear speckles and consist of an evolutionarily conserved protein kinase domain and a homeoprotein-interacting domain. Physiological functions of HIPK3 have been predicted in different cell signaling pathways including transcriptional co-repression, cell differentiation, growth suppression, steroidogenesis and apoptosis. Research suggests that HIPK3 is a FADD-interacting protein kinase found to phosphorylate FADD and promote its binding to Fas, thereby inhibiting Fas-mediated Jun NH (2)-terminal kinase activation. HIPK3 also has been found to phosphorylate JNK and c-JUN, thus enhancing SF-1 activity for CYP11A1 transcription. HIPK3 plays a key role in cAMP-dependant signaling pathway.
Androgen receptor-interacting nuclear protein kinase; ANPK; DYRK6; Fas-interacting serine/threonine-protein kinase; FIST; FIST3; HCMV-interacting protein; Homeodomain-interacting protein kinase 3; Homolog of protein kinase YAK1; Nbak3; Nuclear body-associated kinase 3; nuclear serine/threonine protein kinase; PKY; RP1-8L15.1; YAK1