Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. May act as a tumor suppressor.
HOD; Homeodomain-only protein; HOP; HOPX; LAGY; Lung cancer-associated Y protein; NECC1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; OB1; Odd homeobox protein 1