HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
homeo box 1I; homeo box 4F; homeo box A11; homeo box D11; Homeobox protein Hox-1.9; Homeobox protein Hox-1I; Homeobox protein Hox-4.6; Homeobox protein Hox-4F; Homeobox protein Hox-5.5; Homeobox protein Hox-A11; Homeobox protein Hox-D11; homeobox protein HOXA11; Hox-4.6, mouse, homolog of; HOX11
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