This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in lung and gut development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML) and the occurrence of bronchopulmonary sequestration (BPS) and congenital cystic adenomatoid malformation (CCAM) tissue.
homeo box 2A; homeo box B5; Homeobox protein HHO.C10; Homeobox protein Hox-2A; Homeobox protein Hox-B5; Homeobox protein Hu-1; HOX2A; HOXB5