The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF-kappa-B inducing kinae (NIK) and of NF-kappa-B, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.
C3orf13, IL-1RAcP, IL1R3; IL-1 receptor accessory protein; IL-1R-3; IL-1R3; Interleukin-1 receptor 3; Interleukin-1 receptor accessory protein; interleukin-1 receptor accessory protein beta