JIK or Serine/threonine-protein kinase (TAO3) acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. TAO3 acts as an activator of the p38/MAPK14 stress-activated MAPK cascade, as well. In response to DNA damage, it's involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. TAO3 inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF).
CTCL-associated antigen HD-CL-09; Cutaneous T-cell lymphoma-associated antigen HD-CL-09; Dendritic cell-derived protein kinase; DPK; hKFC-A; JNK/SAPK-inhibitory kinase; Jun kinase-inhibitory kinase; Kinase from chicken homolog A; Serine/threonine-protein kinase TAO3; STE20-like kinase; Thousand and one amino acid protein 3; JIK; KDS; MAP3K18