KCNIP4 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin.
A-type potassium channel modulatory protein 4; CALP; Calsenilin-like protein; KCHIP4; Kv channel interacting protein 4; Kv channel-interacting protein 4; potassium channel interacting protein 4; Potassium channel-interacting protein 4