This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression.
Histone demethylase JARID1A; jumonji, AT rich interactive domain 1A (Rbp2 like); Jumonji, AT rich interactive domain 1A (RBP2-like); Jumonji/ARID domain-containing protein 1A; lysine (K)-specific demethylase 5A; Lysine-specific demethylase 5A; RBBP-2; RBBP2; RBP2; retinoblastoma binding protein 2; Retinoblastoma-binding protein 2