The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11. 3-Xp11. 23. Alternative splicing results in two transcript variants having different 5' UTRs, but encoding the same protein.
CD158 antigen-like family member I; CD158i; Killer cell immunoglobulin-like receptor 2DS4; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; killer Ig receptor; killer inhibitory receptor 4-1-2; killer-cell immunoglobulin-like receptor; KIR antigen 2DS4; MHC class I NK cell receptor; natural killer cell inhibitory receptor; Natural killer-associated transcript 8; NKAT-8; p50 killer cell activating receptor KAR-K1d; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17