KLB is a single-pass type III membrane protein. It contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. KLB is probably inactive as a glycosidase. It increases the ability of FGFR1 and FGFR4 to bind FGF21.
Beta-klotho; betaKlotho; BKL; Klotho beta; klotho beta like; klotho beta, pseudogene 1; Klotho beta-like protein; MGC142213