This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer or a homodimer whereas a third form, MAT II , is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
Cartilage matrix protein; MAT1A; MATA1; matrilin 1, cartilage matrix protein 1; Matrilin-1; SAMS; SAMS1
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