There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regulators of MAPK activity in mammalian cells. MKP2 (DUSP4) is a dual threonine/tyrosine phosphatase that specifically dephosphorylates and inactivates MAPKs (ERK, JNK, p38). It contains one Rhodanese domain and one tyrosine-protein phosphatase domain. MKP2 is expressed in a variety of tissues, and is localized in the nucleus. Transcription factor E2F-1 acts as a transcriptional regulator of MKP2. E2F-1/MKP2 pathway mediates apoptosis under oxidative stress and that MKP2 suppresses tumor formation. MKP2 is a novel transcription target of p53 in mediating apoptosis by 10-bp palindrome motif (CTGGCGCCAG) in the MKP2 promoter.
3CH134/CL100 PTPase; CL 100; CL100; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase 4; Dual specificity protein phosphatase hVH1; Dual specificity protein phosphatase hVH2; DUSP 4; DUSP-4; MAP kinase phosphatase 1; MAP kinase phosphatase 2; MAP kinase phosphatase-1; mitogen-activated protein (MAP) kinase phosphatase-1; Mitogen-activated protein kinase phosphatase 1; Mitogen-activated protein kinase phosphatase 2; mitogen-activated protein kinase phosphatase-1; MKP II; MKP-1; MKP-2; MKP1; MKPII; oxidative stress-inducible protein tyrosine phosphatase; protein tyrosine phosphatase non-receptor type 16; protein tyrosine phosphatase, non-receptor type 16; Protein-tyrosine phosphatase 3CH134; Protein-tyrosine phosphatase CL100; Protein-tyrosine phosphatase ERP; Protein-tyrosine phosphatase non-receptor type 16; PTPN10; serine/threonine specific protein phosphatase; VH1; VH1 homologous phosphatase 2