Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits.
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MCBPE; MOCO1; MOCO1-A; MOCO1-B; MOCS2A; MOCS2B; molybdenum cofactor; molybdenum cofactor biosynthesis protein E; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2 small subunit; Molybdenum cofactor synthesis protein 2A; Molybdenum cofactor synthesis protein 2B; Molybdopterin synthase catalytic subunit; molybdopterin synthase small and large subunit; Molybdopterin synthase sulfur carrier subunit; Molybdopterin-synthase large subunit; Molybdopterin-synthase small subunit; MPT synthase large subunit; MPTS; Sulfur carrier protein MOCS2A