Orphan receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. May regulate the function of nociceptive neurons by modulation of pain perception. Expressed in a subset of IB4-positive small diameter nociceptive dorsal root neurons.
G protein-coupled receptor MRGX3; G protein-coupled receptor SNSR1; G protein-coupled receptor SNSR2; Hdrr1; HDRR2; Mas-related G-protein coupled receptor member X3; Mas-related GPCR member X3; MAS-related GPR; MAS-related GPR, member X3; member X3; MRGPRX3; MRGX3; Sensory neuron-specific G-protein coupled receptor 1/2; SNSR1; SNSR2