Myosins are highly conserved, ubiquitously expressed proteins that interact with actin to generate the force for cellular movements. The human genome encodes over 40 different Myosin genes which are divided into distinct classes, the most notable of which are the conventional Myosins (class II) and the unconventional Myosins (classes I and III through XVIII). Myosin IIIb (MYO3B) is a 1,341 amino acid cytoplasmic and cytoskeletal protein that is though to have an actin-based motor and possesses protein kinase activity. Expressed in testis, retina and kidney, Myosin IIIb exists as seven alternatively spliced isoforms that belong to the STE Ser/Thr protein kinase family and protein kinase superfamily. Myosin IIIb contains one Myosin head-like domain, a protein kinase domain and two IQ domains.
MYO3B; Myosin IIIb; Myosin-IIIb