NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP8 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It maps to chromosome 19q13.42 and is thought to be expressed in testis and ovary, suggesting that NALP8 may be involved in reproduction. Surprisingly, NALP8 seems to be universal in mammals except for rodents, suggesting that the gene may have been lost during evolution.
CLR19.2, NALP8, NOD16, PAN4; NACHT, leucine rich repeat and PYD containing 8; NACHT, LRR and PYD containing protein 8; NACHT, LRR and PYD domains-containing protein 8; NLR family, pyrin domain containing 8; Nucleotide-binding oligomerization domain protein 16; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 8; PYRIN and NACHT-containing protein 4