NF-1, also designated CTF, consists of a family of CCAAT box binding proteins that stimulate DNA replication and activate transcription. Analysis of human NF-1 messenger RNA has revealed two forms of the NF-1 protein arising from an alternate splicing of a single NF-1 gene. NF-1 binds its consensus DNA element as a homodimer via an amino-terminal DNA binding domain, and activates transcription through a putatively novel, proline-rich, carboxy terminal transactivation domain. The NF-1 protein has been shown to recognize and bind the adenovirus type 2 promoter and activate transcription of herpes simplex virus thymidine kinase genes. The NF-1 consensus element has been found in the upstream promoter region of myriad eukaryotic genes, including that of Ha-Ras, alpha-globin, HSP 70, GRP 78, Histone H1, myelin basic protein and in the Xenopus laevis vitellogenin gene promoter.
CCAAT-binding transcription factor; CCAAT-box-binding transcription factor; CTF; KIAA1439; NF-I/A; NF-I/B; NF-I/C; NF-I/X; NF1-A; NF1-B; NF1-C; NF1-X; NFI; NFI-A; NFI-B; NFI-C; NFI-X; NFIA; NFIB; NFIC; NFIX; Nuclear factor 1 A-type; Nuclear factor 1 B-type; Nuclear factor 1 C-type; Nuclear factor 1 X-type; nuclear factor 1-C2; Nuclear factor 1/A; Nuclear factor 1/B; Nuclear factor 1/C; Nuclear factor 1/X; Nuclear factor I/A; Nuclear factor I/B; Nuclear factor I/C; nuclear factor I/C (CCAAT-binding transcription factor); Nuclear factor I/X; nuclear factor I/X (CCAAT-binding transcription factor); olfactory epithelium nuclear factor I-B; olfactory epithelium nuclear factor I-C; TGGCA-binding protein