NY-ESO-1, a member of the cancer/testis (CT) family, is a tumor-specific shared antigen with distinctive immunogenicity. Cancer/testis antigens are expressed in a range of malignant neoplasms such as melanoma and carcinomas of the breast, ovary and lung, but not in normal tissue except in testis. NY-ESO-1 reactivity in testis is restricted germ cells, particularly in the spermatogonia. NY-ESO-1 is a classic CT antigen discovered during a SEREX analysis of esophageal cancer. Among these antigens, NY-ESO-1 is of particular interest because both the cytotoxic T lymphocyte and antibody have been shown to react with this antigen. It is a 22-23 KDa hydrophobic protein.
Autoimmunogenic cancer/testis antigen NY-ESO-1; Cancer/testis antigen 1; cancer/testis antigen 1-A; Cancer/testis antigen 6.1; CT6.1; CTAG; CTAG1; CTAG1A; CTAG1B; ESO1; L antigen family member 2; LAGE-2; LAGE2; LAGE2A; LAGE2B; New York Esophageal Squamous Cell Carcinoma 1