Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI3.
calcium release-activated calcium channel 2; CAP-binding protein complex interacting protein 2; CAP-binding protein complex-interacting protein 2; H_NH0514P08.8; PP1729, C7orf19, CBCIP2, MEM142B, TMEM142B; Protein orai-2; putative protein ORAI2-2; Transmembrane protein 142B