P2Y6 belongs to the family of G protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. P2Y6 expression has been documented in various blood cells, bone marrow, brain, colon, heart, kidney, ovary, placenta, spleen,and thymus. ESTs have been isolated from cervix, embryo, eye, kidney, liver/spleen, placenta, and vessel libraries.
G-coupled nucleotide receptor; P2 purinoceptor; P2RY6; P2Y ATP receptor 6; P2Y purinoceptor 6; P2Y6; P2Y6 receptor; pyrimidinergic receptor P2Y, G-protein coupled, 6