PIGM encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI)-anchor is a glycolipid which contains three mannose molecules in its core backbone. The GPI-anchor is found on many blood cells and serves to anchor proteins to the cell surface. PIGM encodes a mannosyltransferase, GPI-MT-I, that transfers the first mannose to GPI on the lumenal side of the endoplasmic reticulum.
dol-P-Man dependent GPI mannosyltransferase; DPM:GlcN-(acyl-)PI mannosyltransferase; GPI mannosyltransferase 1; GPI mannosyltransferase I; GPI-MT-I; phosphatidylinositol glycan anchor biosynthesis, class M; Phosphatidylinositol-glycan biosynthesis class M protein; PIG-M; PIG-M mannosyltransferase