POM121 (POM121 membrane glycoprotein), also known as POM121A (nuclear envelope pore membrane protein POM 121A), NUP121 (nucleoporin Nup121) or pore membrane protein of 121 kDa, is a 1,249 amino acid single-pass membrane protein that exists as three alternatively spiced isoforms and belongs to the POM121 family. Encoded by a gene that maps to human chromosome 7q11. 23, POM121 is highly conserved and localizes to nucleus membrane and endoplasmic reticulum membrane. An essential component of the nuclear pore complex (NPC), POM121 is mandatory for nuclear envelope formation and may play a role in biogenesis of the NPC. POM121 associates with the central spoke ring complex and is involved in anchoring components of the pore complex to the pore membrane by way of its F-X-F-G repeat-containing domain. POM121 overexpression induces the formation of cytoplasmic annulate lamellae (AL).
DKFZp586G1822 antibody; DKFZp586P2220 antibody; FLJ41820 antibody; KIAA0618 antibody; MGC3792 antibody; Nuclear envelope pore membrane protein POM 121; nuclear envelope pore membrane protein POM 121 antibody; Nuclear envelope pore membrane protein POM 121A; nuclear envelope pore membrane protein POM 121A antibody; nuclear pore membrane protein 121 kDa; nuclear pore membrane protein 121 kDa antibody; Nucleoporin Nup121; nucleoporin Nup121 antibody; P145 antibody; POM121 antibody; POM121 membrane glycoprotein; POM121 membrane glycoprotein antibody; POM121A antibody; Pore membrane protein of 121 kDa; pore membrane protein of 121 kDa antibody