This gene encodes a member of the ASPP family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor.
Apoptosis-stimulating of p53 protein 1; apoptosis-stimulating protein of p53, 1; ASPP1; KIAA0771; PPP1R13B; Protein phosphatase 1 regulatory subunit 13B; protein phosphatase 1, regulatory (inhibitor) subunit 13B; protein phosphatase 1, regulatory subunit 13B; transformation related protein 53 binding protein 2; tumor protein p53 binding protein, 2; tumor protein p53-binding protein, 2