Prostaglandins (PG's) are produced by the metabolism of arachidonic acid. PGE-2 is one of the five physiologically significant prostanoids known. It's wide spectrum of physiologic and pharmacologic effects in various tissues are mediated through binding to the PGE-2 receptors (EP1, EP2, EP3 and EP4). These include effects on the immune, endocrine, cardiovascular, renal and reproductive systems as well as smooth muscle. It is also one of the most abundant of the prostanoid family in the brain where it plays an important role in many neural functions, particularly in newborn babies, and as a mediator of inflammation.
EP2 receptor; PGE receptor EP2 subtype; PGE receptor EP3 subtype; PGE receptor, EP2 subtype; PGE receptor, EP3 subtype; PGE2 receptor EP2 subtype; PGE2 receptor EP3 subtype; PGE2-R; prostaglandin E receotor EP3 subtype 3 isoform; prostaglandin E receptor 2 (EP2 subtype); prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E receptor 3 (subtype EP3); prostaglandin E receptor EP2 subtype; prostaglandin E receptor EP3 subtype; prostaglandin E receptor subtype EP2; Prostaglandin E2 Receptor EP2 + EP3; Prostaglandin E2 receptor EP2 subtype; Prostaglandin E2 receptor EP3 subtype; prostaglandin E2 receptor type 2; prostaglandin receptor (PGE-2); Prostanoid EP2 receptor; Prostanoid EP3 receptor; PTGER2; PTGER3