This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
PURB; PurB beta; purine-rich element binding protein B; Purine-rich element-binding protein B; purine-rich single-stranded DNA-binding protein beta; transcription factor Pur-beta; Transcriptional activator protein Pur-beta; Vascular actin single-stranded DNA-binding factor 2 p44 component