Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.
cancer/testis antigen 102; Centrosome-related protein TCC52; CT102, KIAA1892, TCC52, WDR40A; DDB1- and CUL4-associated factor 12; similar to WD repeat domain 40A; Testis cancer centrosome-related protein; WD repeat domain 40A; WD repeat-containing protein 40A