S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.
Dimethyladenosine transferase 2, mitochondrial; FLJ22661; FLJ23182; h-mtTFB; h-mtTFB2; HCV NS5A-transactivated protein 5; Hepatitis C virus NS5A-transactivated protein 5; Hkp1; hTFB2M; Mitochondrial 12S rRNA dimethylase 2; Mitochondrial transcription factor B2; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2