The innate immune system recognizes microbial pathogens through Toll-like receptors domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
adapter protein wyatt; Adaptor protein Wyatt; FLJ42305; HGNC:17192; Mal; MyD88 adapter-like protein; MyD88-2; OTTHUMP00000179130; TIR domain-containing adapter protein; TIRAP; toll-interleukin 1 receptor (TIR) domain containing adaptor protein; Toll-interleukin 1 receptor (TIR) domain-containing adapter protein; Toll-interleukin 1 receptor domain-containing adaptor protein; Toll-like receptor adaptor protein; Toll/interleukin-1 receptor domain-containing adapter protein; wyatt
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