The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).
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homeo box 11-like 2; Homeobox protein Hox-11L2; Homeobox TLX-3; HOX11L2 Antibody; Respiratory neuron homeobox protein; RNX Antibody; T-cell leukemia homeobox 3 Antibody; T-cell leukemia homeobox protein 3; T-cell leukemia, homeobox 3