Mast cells contain a number of preformed chemical mediators such as histamine, chymase, carboxypeptidase and proteolytic tryptase. A substantial quantity of tryptase is estimated to be found in mast cells of skin and lung and suggestes this enzyme plays a major role in mast cell mediated events. In vitro studies indicate tryptase can cleave C3 to form C3a anaphylatoxin, inactivate fibrinogen as a coaguable substrate for thrombin and activate latent collagenase. Human mast cell tryptase has considerable potential as a marker for mast cell activation as well as being a mediator of inflammation.
mast cell alpha II tryptase; mast cell beta I tryptase; tryptase alpha II; Tryptase alpha-1; Tryptase alpha/beta-1; tryptase beta 1; tryptase beta I; tryptase beta-1; Tryptase beta-2; Tryptase I; Tryptase II; Tryptase-1; Tryptase-2; tryptase-I; tryptase-III