The Trip230 gene encodes a protein of 1,978 amino acids with an estimated molecular mass of 230 kDa. The gene is located on chromosome 14q31, which is in a region associated with genetic alterations and thyroid hormone response abnormalities. The Trip230 protein interacts with Rb and thyroid hormone receptor (TR) using two distinct domains. Complex formation with Rb is in a hormone independent manner, but when Trip230 forms a complex with TR, it is in a thyroid hormone-dependent manner. After T3 treatment, Trip230 is phosphorylated and transported to the nucleus, suggesting that phosphorylation may be important for its nuclear translocation.
ACG1A; CEV14; Clonal evolution-related gene on chromosome 14 protein; GMAP-210; Golgi-associated microtubule-binding protein 210; Golgi-microtubule-associated protein of 210 kDa; Thyroid receptor-interacting protein 11; TR-interacting protein 11; TRIP230