UNC5CL is a membrane protein belonging to theUNC-5 family with a death domain and a ZU5 domain and is known to interact with p65/RELA and NFKB1. UNC5CL is known to interact with subunit p105 of NF-kappaB and transactivator p65 and is thus involved in inhibition of NF-kappaB activation and NF-kappaB-dependent transcription by inhibiting the binding of NF-kappaB to its target sequence (providing an alternative regulatory mechanism for NF-kappaB-mediated transcription). This regulatory protein sensitizes cells to apoptosis induced by TNF and TRAIL.
MGC34763; OTTHUMP00000016362; Protein unc-5 homolog C-like; unc-5 homolog C (C. elegans)-like; UNC5C-like protein; zu-5; ZU5 and death domain containing; ZU5 and death domain-containing protein
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