The protein encoded by this gene is a deubiquitylase that binds ERCC1, the catalytic subunit of the XPF-ERCC1 DNA repair endonuclease. This endonuclease is a critical regulator of DNA repair processes, and the deubiquitylase activity of the encoded protein is important for maintaining the DNA repair ability of XPF-ERCC1.
Deubiquitinating enzyme 45; granule cell antiserum positive 7; Ubiquitin carboxyl-terminal hydrolase 45; ubiquitin specific petidase 45; ubiquitin specific protease 45; Ubiquitin thioesterase 45; ubiquitin thiolesterase 45; Ubiquitin-specific-processing protease 45
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