The family of T1/35 kDa proteins are secreted, soluble proteins encoded by the 35K virulence gene of many poxviruses. These proteins bind CC chemokines with high affinity and are now termed viral chemokine inhibitors (vCCI). Vaccinia virus (Strain Lister) vCCI shows greater than 90% amino acid sequence identity with vCCI from other orthopoxviruses and approximately 40% amino acid sequence identity with the leporipoxvirus T-1 proteins.View more
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