This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. Among members of the human WNT family, WNTB is most similar to WNT7A protein.
Protein Wnt-7a; Protein Wnt-7b; proto-oncogene Wnt7a protein; proto-oncogene Wnt7b protein; wingless-type MMTV integration site family member 7A; wingless-type MMTV integration site family member 7B; wingless-type MMTV integration site family, member 7A; wingless-type MMTV integration site family, member 7B