This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in normal testis, and in Ewing's sarcoma, rhabdomyosarcoma, a breast cancer and a germ cell tumor. The protein encoded by this gene shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens.
Cancer/testis antigen 12.2; cancer/testis antigen family 12, member 2; CT12.2; G antigen family D member 3; GAGED3; X antigen family member 2; X antigen family, member 2; X antigen family, member 2B; XAGE-2; XAGE2; XAGE2B