Yersinia pestis V antigen (LcrV) is an environmentally regulated, plasmid pCD1-encoded protein. Yersinia pestis is the etiologic agent of plague, and LcrV is a multifunctional protein that has been shown to act at the level of secretion control by binding the Ysc inner-gate protein LcrG and to modulate the host immune response by altering cytokine production. LcrV also is essential for the unidirectional targeting of Yops to the cytosol of infected eukaryotic cells.
Bubonic Plague; Pasturella pestis; yersinia pseudotuberculosis
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