Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Beta-III tubulin is primarily expressed in neurons and may be involved in neurogenesis, axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Beta-III tubulin was also detected in Sertoli cells of the testis and transiently in non-neuronal embryonic tissues. Glutamate residues at the C-terminus of beta III tubulin can be glutamylated. The precise function of such modifications is unclear. Tubulin is phosphorylated on Ser-172 by CDK1 during cell cycle progression. Ser-172 phosphorylation inhibits tubulin incorporation into microtubules.
beta 3; beta 3 class III; beta-4; betaIII-tubulin; CDCBM; CFEOM3A; class III beta-tubulin; Neuron-specific class III beta-tubulin; TUBB4; tubulin; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III; tubulin, beta 3 class III
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