Disulfide-bond-A oxidoreductase-like protein (DsbA-L, previously named as GST Kappa) is an adiponectin-interacting protein. DsbA-L is highly expressed in adipose tissue, and its expression level is negatively correlated with obesity in mice and humans. DsbA-L expression in 3T3-L1 adipocytes is stimulated by the insulin sensitizer rosiglitazone and inhibited by the inflammatory cytokine TNFalpha. Overexpression of DsbA-L promotes adiponectin multimerization while suppressing DsbA-L expression by RNAi markedly and selectively reduces adiponectin levels and secretion in 3T3-L1 adipocytes.
glutathione S-transferase class kappa; glutathione S-transferase k1; Glutathione S-transferase kappa 1; Glutathione S-transferase subunit 13; glutathione S-transferase subunit 13 homolog; glutathione S-transferase, mitochondrial; GST 13-13; GST class-kappa; GST13; GST13-13; GSTK1-1; hGSTK1; mGSTK1; rGSTK1