uPA binding to uPAR stimulates the interaction of uPAR with integral membrane proteins, such as integrins, which signal intracellularly to promote cytoskeletal reorganization and cell migration. The urokinase receptor (uPAR) consists of three internally disulfide-bonded domains and is attached to the cell surface by a glycosyl phosphatidylinositol (GPI) anchor. Upon cleavage of the GPI, uPAR is released from the plasma membrane into its soluble form. Both uPAR and soluble uPAR (suPAR) can be cleaved in the region that links domains D1 to D2 to yield a D1 and D2D3 fragment, which has direct chemotactic activity.
InvitrogenCD87 (UPAR) Monoclonal Antibody (VIM5), APC, eBioscience™ CD87 (UPAR) Monoclonal Antibody (VIM5), APC, eBioscience™
Cat # 17-3879-42
InvitrogenCD87 (UPAR) Monoclonal Antibody (VIM5), PerCP-eFluor 710, eBioscience™ CD87 (UPAR) Monoclonal Antibody (VIM5), PerCP-eFluor 710, eBioscience™
Cat # 46-3879-42
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.