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Two isoforms were produced by alternative splicing with predicted MW of 52 and 43 kDa. 11499-1-AP can recognize both forms.
Immunogen sequence: MERKDFETW LDNISVTFLS LTDLQKNETL DHLISLSGAV QLRHLSNNLE TLLKRDFLKL LPLELSFYLL KWLDPQTLLT CCLVSKQWNK VISACTEVWQ TACKNLGWQI DDSVQDALHW KKVYLKAILR MKQLEDHEAF ETSSLIGHSA RVYALYYKDG LLCTGSDDLS AKLWDVSTGQ CVYGIQTHTC AAVKFDEQKL VTGSFDNTVA CWEWSSGART QHFRGHTGAV FSVDYNDELD ILVSGSADFT VKVWALSAGT CLNTLTGHTE WVTKVVLQKC KVKSLLHSPG DYILLSADKY EIKIWPIGRE INCKC (1-314 aa encoded by BC018738)
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: F-box and WD-40 domain protein 2; F-box and WD-40 domain-containing protein 2; F-box and WD-40 domain-containing protein 2 {ECO:0000312|EMBL:AAI66990.1}; F-box protein Fbw2; F-box/WD repeat-containing protein 2; fbxw2 {ECO:0000312|RGD:1310460}; MGC117371; Protein MD6
Gene Aliases: 2700071L08Rik; FBW2; FBXW2; FWD2; MD6
UniProt ID: (Human) Q9UKT8, (Rat) B2RZ17
Entrez Gene ID: (Human) 26190, (Rat) 311881, (Mouse) 30050
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