Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MSLGPEVFL GPPEAQSFLS SHTRIPRANH WDLELLTPGN LERECLEERC SWEEAREYFE DNTLTERFWE SYIYNGKGGR GRVDVASLAV GLTCGILLIV LAGLGAFWYL RWRQHRGQQP CPQEAGLISP LSPLNPLGPP TPLPPPPPPP PGLPTYEQAL AASGVHDAPP PPYTSLRRPH (1-179 aa encoded by BC026032)
PRRG2 encodes a protein that is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NEDD4 WW domain-binding protein 1; proline rich Gla (G-carboxyglutamic acid) 2; Proline-rich gamma-carboxyglutamic acid protein 2; proline-rich Gla (G-carboxglutamic acid) polypeptide 2; proline-rich Gla (G-carboxyglutamic acid) polypeptide 2; Proline-rich Gla protein 2; Transmembrane gamma-carboxyglutamic acid protein 2
Gene Aliases: 1600014G02Rik; 2510041M06Rik; N4WBP1; PRGP2; PRRG2; TMG2
UniProt ID: (Human) O14669, (Mouse) Q8R182
Entrez Gene ID: (Human) 5639, (Rat) 361570, (Mouse) 65116
Molecular Function: serine protease
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