This antibody is predicted to react with bovine, chicken, mouse, non-human primate, rat and zebrafish based on sequence homology.
YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 14-3-3 alpha; 14-3-3 protein beta/alpha; 14-3-3 protein beta/alpha, N-terminally processed; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1; Protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Gene Aliases: GW128; HEL-S-1; HS1; KCIP-1; YWHAA; YWHAB
UniProt ID: (Human) P31946
Entrez Gene ID: (Human) 7529
Molecular Function: chaperone