This antibody specifically recognizes gamma isoform of 14-3-3.
Immunogen sequence: MVDREQLVQ KARLAEQAER YDDMAAAMKN VTELNEPLSN EERNLLSVAY KNVVGARRSS WRVISSIEQK TSADGNEKKI EMVRAYREKI EKELEAVCQD VLSLLDNYLI KNCSETQYES KVFYLKMKGD YYRYLAEVAT GEKRATVVES SEKAYSEAHE ISKEHMQPTH PIRLGLALNY SVFYYEIQNA PEQACHLAKT AFDDAIAELD TLNEDSYKDS TLIMQLLRDN LTLWTSDQQD DDGGEGNN (1-247 aa encoded by BC020963)
14-3-3 gamma encodes a product that belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 14-3-3 gamma; 14-3-3 protein gamma; 14-3-3 protein gamma subtype; 14-3-3 protein gamma, N-terminally processed; 14-3-3 protein gamma-subtype; 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; KCIP-1; Protein kinase C inhibitor protein 1; protein phosphatase 1, regulatory subunit 170; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide
Gene Aliases: 14-3-3G; 14-3-3GAMMA; D7Bwg1348e; PPP1R170; YWHAG
Molecular Function: scaffold/adaptor protein