This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
MA5-11663 targets 14-3-3 sigma in ICC/IF, IHC (P), IP, and WB applications and shows reactivity with Human samples.
The MA5-11663 immunogen is recombinant human 1433 sigma protein.
14.3.3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14.3.3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14.3.3 and target proteins are strongly influenced by the phosphorylation state of 14.3.3 and the target protein. 14.3.3 sigma shares cyclin-Cdk2 binding motifs with different cell cycle regulators, including p107, p130, p21Cip1, p27Kip1, and p57Kip2 and is associated with cyclin-Cdk complexes in vitro and in vivo.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 14-3-3 protein sigma; 14-3-3 sigma; Epithelial cell marker protein 1; Stratifin
Gene Aliases: HME1; SFN; YWHAS
UniProt ID: (Human) P31947
Entrez Gene ID: (Human) 2810
Molecular Function: chaperone