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|Tested species reactivity||Bovine, Human, Mouse, Rat|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant 14-3-3-theta/tau protien.|
|Storage buffer||PBS, pH 7.5, with 50% glycerol|
|Contains||3mM sodium azide|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||1:5000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
MA1-12431 does not react with the XI isoform.
A suggested positive control for this product is NIH-3T3, PC12 or Jurkat lysate.
At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
14-3-3; 14-3-3 eta; 14-3-3 protein eta; 14-3-3 protein eta-subtype; 14-3-3 protein T-cell; 14-3-3 protein tau; 14-3-3 protein theta; 14-3-3 tau; 14-3-3 theta; 1C5; HS1; KCIP-1; protein kinase C inhibitor protein 1; protein, theta; tyrosine 3-monooxygenase/tryotophan 5-monooxygenase activation protein; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide
14-3-3; 14-3-3e; 14-3-3t; 1C5; 2700028P07Rik; AA409740; AU021156; BOS_11879; BOS_16771; HS1; R74690; YWHA1; YWHAH; YWHAQ