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Invitrogen
20S Proteasome Monoclonal Antibody (863437)
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Product Details
MA5-62036
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
863437
Immunogen
Human 20S Proteasome purified from human erthrocytes
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
The 20S proteasome is a core component of the proteasome complex, which plays a crucial role in the degradation of intracellular proteins. This multi-subunit protease complex is essential for maintaining cellular homeostasis by selectively degrading misfolded, damaged, or unneeded proteins, thus regulating various cellular processes, including the cell cycle, signaling pathways, and stress responses. The 20S proteasome is composed of 28 subunits arranged in a barrel-shaped structure with two outer alpha-rings and two inner beta-rings, which house the proteolytic active sites. Proteins targeted for degradation are typically tagged with ubiquitin molecules, recognized by the regulatory 19S cap complex, and then translocated into the 20S core for proteolysis. The proper functioning of the 20S proteasome is vital for cellular health, and its dysfunction is associated with a range of diseases, including neurodegenerative disorders like Alzheimer's and Parkinson's disease, where protein aggregation occurs, and cancer, where proteasome inhibitors are used as therapeutic agents. Understanding the structure, function, and regulation of the 20S proteasome is key for developing new therapeutic strategies aimed at modulating proteasome activity for the treatment of various diseases. Research into the 20S proteasome continues to provide insights into its broader role in cellular physiology and its potential as a target for drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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