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Staining of 3-day unstimulated (top) and 3-day Anti-Mouse IgM and Anti-Mouse CD40-stimulated (bottom) mouse splenocytes with 0.5 ug of Rat IgG2a kappa Isotype Control PE (blue histogram) or 0.5 ug of Anti-Mouse CD137 Ligand (4-1BB Ligand) PE (A16402) (purple histogram). Total viable CD45R (B220)+ cells were used for analysis.
|Tested species reactivity||Mouse|
|Host / Isotype||Rat / IgG2a, kappa|
|Immunogen||Mouse CD137 Ligand Protein|
|Storage buffer||proprietary buffer|
|Contains||0.09% sodium azide|
|Storage Conditions||4° C|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
4-1BBL, Cd137l, AI848817, Ly63l, 4-1BB-L
4-1BB ligand, tumor necrosis factor ligand superfamily member 9, TNFSF9, 4-1BB-L, CD137 Ligand, 4-1BBL, homolog of mouse 4-1BB-L, receptor 4-1BB ligand