Immunogen sequence: HQPSQSRAIP TRTVAISDAA QLPHDYCTTP
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 97%.
This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection.
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Protein Aliases: 4E-BP2; eIF4E-binding protein 2; Eukaryotic translation initiation factor 4E-binding protein 2; phosphorylated, heat and acid stable regulated by insulin protein II
Gene Aliases: 4EBP2; EIF4EBP2; PHASII
UniProt ID: (Human) Q13542
Entrez Gene ID: (Human) 1979