Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds – the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody – recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets – a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
Toll-like receptor 4, proteoglycans and bacterial DNA. TLRs have been shown to initiate inflammatory responses upon recognition of pathogen-derived substances. TLR4 is expressed by peripheral blood monocytes and a small population of B-cells and is also expressed in human placenta. Mammalian cells respond to LPS by activating TLR4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ARMD10; CD284; homolog of Drosophila toll; hToll; lipopolysaccharide response; TLR-4; TOLL; Toll-like Receptor 4
Gene Aliases: ARMD10; CD284; Lps; Ly87; Ran/M1; Rasl2-8; TLR-4; TLR4; TOLL